Abstract Detail

Molecular Ecology and Evolution

Nowruzi, Bahareh [1], Khavari-Nejad, Ramezan-Ali [1], Nejadsattari, Taher [1].

On the presence of nosF gene in the four aquatic and terrestrial Nostoc strains revealing antifungal and trypsin inhibitor activity.

Cyanobacteria are one of the most widespread microorganisms on earth, and they are found in almost all ecosystems, from fresh and marine water to terrestrial environments. Nostoc strains received a great deal of attention as prolific producers of bioactive secondary metabolites which are highly toxic to humans and other animals. Discovery of several dead dogs, mice, ducks, and fish around paddy fields, prompted us to study the toxic compounds and characterize novel bioactive natural products from four Nostoc strains isolated from aquatic and terrestrial paddy fields. Results of molecular analysis demonstrated that the only two aquatic strains contain the nosF gene and a remarkable antifungal activity was identified in the methanolic extracts. While trypsin inhibitor was detected from two terrestrial strains. Based on the results, this study suggests that methylproline-containing compounds in two aquatic strains might account for the death of these animals. This case is the first documented incident of toxicity from aquatic cyanobacteria related intoxication in dogs, mice, and aquatic organisms in Iran.

1 - Department of Biology, Science and Research Branch, Islamic Azad Unive
2 - Department of Biology, Science and Research Branch, Islamic Azad Unive
3 - Department of Biology, Science and Research Branch, Islamic Azad Unive

Keywords:
Natural bioactive compound; Toxicity; nosF gene.

Presentation Type: Oral Paper
Session: 40, Molecular Ecology and Evolution
Location: 102/Savannah International Trade and Convention Center
Date: Wednesday, August 3rd, 2016
Time: 11:30 AM
Number: 40013
Abstract ID:47
Candidate for Awards:None